Apocofart (Noun) A high-pitched, piercing flatulent noise that will actually end all life on the planet, before blowing the Earth into complete oblivion.

There is only one way to trigger an apocofart: Casting both Fran Drescher and Rosie O'Donnell in the same television sitcom. The end is nigh, folks.

Fran Drescher will be co-starring with Rosie O’Donnell in a new television show, the details of which are still under wraps, but O’Donnell says it will be about three best friends. (Source)

My advice: Do what I'm going to do -- self-inflicted water torture, disembowelment and a shotgun blow to the face; it's the only way to prepare yourself for pain of this magnitude.